Description

2,2-Difluorocyclohexanamine Hydrochloride is a high-purity fluorinated amine salt with the CAS number 921602-83-7. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its ability to introduce both fluorine atoms and an amine functional group into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including potential CNS agents and enzyme inhibitors.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides, where the difluoro motif can enhance biological activity and metabolic stability.
• Organic Synthesis Building Block: Employed in medicinal chemistry for constructing complex, stereodefined cyclohexylamine derivatives via further functionalization.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated for incorporation into specialty polymers and advanced materials to modify physical and chemical properties.

Basic Information

Product Name	2,2-Difluorocyclohexanamine Hydrochloride
CAS No.	921602-83-7
Molecular Formula	C6H12ClF2N
Molecular Weight	183.62 g/mol
Synonyms	2,2-Difluorocyclohexanamine HCl; 2,2-Difluorocyclohexylamine Hydrochloride; trans/cis-2,2-Difluorocyclohexanamine Hydrochloride; 1-Amino-2,2-difluorocyclohexane Hydrochloride; Cyclohexanamine, 2,2-difluoro-, hydrochloride; 921602-83-7; 2,2-Difluoro-1-cyclohexanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluorocyclohexanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.