Description

Nebivolol (R,R,S,R)-Isomer is a specific stereoisomer of the β-blocker Nebivolol, identified by the CAS registry number 920275-20-3. This high-purity intermediate is critical for the research and development of enantiomerically pure pharmaceutical compounds, particularly in cardiovascular therapeutics. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on chiral synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for cardiovascular drugs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Chiral Research: Serves as a critical substrate in stereochemistry studies, asymmetric synthesis research, and the development of novel chiral separation techniques.
• Process Development: Employed in scaling up and optimizing synthetic routes for the commercial production of enantiomerically pure Nebivolol or its derivatives.
• Metabolite Studies: Utilized in pharmacological and pharmacokinetic research to investigate drug metabolism pathways.

Basic Information

Product Name	Nebivolol (R,R,S,R)-Isomer
CAS No.	920275-20-3
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	1-(6-Fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amino]ethanol (R,R,S,R)-Isomer; Nebivolol Stereoisomer; Nebivolol Related Compound; (2R,2'R,1''S,2''R)-Nebivolol; UNII-7K3306012U; Bystolic Isomer; R,R,S,R-Nebivolol
EINECS	Contact for details

Quality Control

Our Nebivolol (R,R,S,R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by spectroscopic methods, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.