Description

4-Bromo-5-Fluoro-2-Methylbenzonitrile is a high-purity, multi-functional halogenated aromatic nitrile building block. This compound is valued for its unique molecular scaffold, which enables the synthesis of complex molecules in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and advanced material scientists as a key intermediate in the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Serves as a versatile building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and advanced polymers due to its halogen-substituted aromatic structure.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tagging reagent in biochemical research and drug discovery platforms.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects and process development.

Basic Information

Product Name	4-Bromo-5-Fluoro-2-Methylbenzonitrile
CAS No.	916792-15-9
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Methyl-4-bromo-5-fluorobenzonitrile; 4-Bromo-5-fluoro-o-tolunitrile; 5-Fluoro-4-bromo-2-methylbenzonitrile; Benzonitrile, 4-bromo-5-fluoro-2-methyl-; 2-Methyl-4-bromo-5-fluorobenzonitrile; 916792-15-9
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-5-Fluoro-2-Methylbenzonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles. Our standard grade meets the rigorous demands of research and process development, with specifications tailored to support cGMP and ISO standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.