Description

4-Bromo-2-Fluoro-5-Methylbenzonitrile is a high-purity halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its unique substitution pattern, which facilitates the introduction of both bromine and fluorine functionalities into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic and optoelectronic applications, including liquid crystal displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct biaryl systems.
• Chemical Research: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and constructing complex, fluorinated aromatic compounds.
• Functional Material Development: Used in the synthesis of specialty polymers, ligands for catalysis, and advanced organic frameworks.

Basic Information

Product Name	4-Bromo-2-Fluoro-5-Methylbenzonitrile
CAS No.	916792-13-7
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Fluoro-4-bromo-5-methylbenzonitrile; 5-Methyl-2-fluoro-4-bromobenzonitrile; Benzonitrile, 4-bromo-2-fluoro-5-methyl-; 4-Bromo-2-fluoro-5-methyl-benzonitrile; 916792-13-7; 4-Bromo-2-fluoro-5-methylbenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-5-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.