Description

2-Bromo-5-Fluoro-4-Methylbenzonitrile is a high-purity, multi-functional halogenated aromatic nitrile building block. This compound is valued for its unique molecular architecture, which enables precise structural modifications in advanced synthetic pathways. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and pesticides, leveraging the bromo and fluoro substituents for bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of specialized liquid crystals, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings for carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical sector.

Basic Information

Product Name	2-Bromo-5-Fluoro-4-Methylbenzonitrile
CAS No.	916792-11-5
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	4-Bromo-2-Fluoro-5-Methylbenzonitrile; 5-Fluoro-4-Methyl-2-Bromobenzonitrile; 2-Bromo-5-fluoro-4-methylbenzenecarbonitrile; Benzonitrile, 2-bromo-5-fluoro-4-methyl-; 916792-11-5
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Fluoro-4-Methylbenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.