Description

2-Bromo-4-Fluoro-5-Methylbenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and nitrile functional groups, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogen-substituted aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms enhance biological activity and stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and specialty polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to form complex biaryl structures.
• Chemical Synthesis Reagent: Employed in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for screening.

Basic Information

Product Name	2-Bromo-4-Fluoro-5-Methylbenzonitrile
CAS No.	916792-07-9
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Bromo-4-fluoro-5-methylbenzonitrile; 5-Methyl-2-bromo-4-fluorobenzonitrile; Benzonitrile, 2-bromo-4-fluoro-5-methyl-; 4-Fluoro-2-bromo-5-methylbenzonitrile; 2-Bromo-4-fluoro-5-methyl-benzonitrile; 916792-07-9 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-5-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.