Description

4-Methoxy-2,3,5-trifluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique trifluorinated methoxybenzene core makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs where it can influence metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where its structure contributes to desired dielectric and luminescent properties.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a precursor for heterocyclic compounds like fluorinated pyridines and pyrimidines.
• Material Science Research: Employed in the development of novel polymers, coatings, and advanced organic frameworks that require specific fluorine incorporation for performance characteristics.

Basic Information

Item	Details
Product Name	4-Methoxy-2,3,5-Trifluorobenzonitrile
CAS No.	916791-82-7
Molecular Formula	C8H4F3NO
Molecular Weight	195.12 g/mol
Synonyms	2,3,5-Trifluoro-4-methoxybenzonitrile; 4-Methoxy-2,3,5-trifluorobenzene carbonitrile; 2,3,5-Trifluoro-4-methoxybenzonitrile; 4-Methoxy-2,3,5-trifluorophenyl cyanide; Benzonitrile, 4-methoxy-2,3,5-trifluoro-; 916791-82-7
EINECS	Contact for details

Quality Control

Our 4-Methoxy-2,3,5-trifluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.