Description

4-Ethoxy-2,6-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both ethoxy and fluorine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules requiring a difluorobenzene core.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the development of organic semiconductors and charge-transport materials due to its electron-withdrawing nitrile group.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination to create biaryl structures.
• Chemical Research: Used in academic and industrial labs for methodological studies and exploring new reaction pathways involving fluorinated aromatics.

Basic Information

Product Name	4-Ethoxy-2,6-Difluorobenzonitrile
CAS No.	916483-58-4
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	2,6-Difluoro-4-ethoxybenzonitrile; Benzonitrile, 4-ethoxy-2,6-difluoro-; 4-Ethoxy-2,6-difluorobenzene carbonitrile; 2,6-Difluoro-4-ethoxybenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2,6-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.