Description

3-(Difluoromethoxy)-4-Fluorobenzonitrile is a high-value fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique difluoromethoxy and fluorine substituents make it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: A valuable monomer or intermediate for creating electron-deficient units in organic semiconductors and polymers.
• Chemical Research: Employed in academic and industrial R&D for exploring novel fluorination chemistry and constructing complex heterocyclic systems.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for synthesizing fluorine-18 labeled radiopharmaceuticals for medical imaging.

Basic Information

Product Name	3-(Difluoromethoxy)-4-Fluorobenzonitrile
CAS No.	916210-09-8
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	4-Fluoro-3-(difluoromethoxy)benzonitrile; 3-(Difluoromethoxy)-4-fluorobenzonitrile; 4-Fluoro-α,α-difluoroanisole-3-carbonitrile; Benzonitrile, 3-(difluoromethoxy)-4-fluoro-; 916210-09-8
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)-4-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.