Description

(S)-4-(Fluoromethyl)-Dihydrofuran-2(3H)-One is a high-value chiral building block and fluorinated intermediate. This compound is significant for its role in the synthesis of complex molecules, particularly in the pharmaceutical sector where the introduction of fluorine atoms and specific stereochemistry is crucial for modulating biological activity and metabolic stability. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material industries for developing new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the fluorine moiety enhances efficacy and environmental persistence.
• Organofluorine Chemistry Research: Serves as a versatile substrate for studying fluorination reactions and constructing complex fluorinated heterocycles in academic and industrial R&D settings.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and catalysts for asymmetric synthesis, critical for producing enantiomerically pure compounds.
• Material Science Precursor: Potential use as a monomer or modifier in the synthesis of specialty polymers and advanced materials with unique properties.

Basic Information

Product Name	(S)-4-(Fluoromethyl)-Dihydrofuran-2(3H)-One
CAS No.	916069-80-2
Molecular Formula	C5H7FO2
Molecular Weight	118.11 g/mol
Synonyms	(S)-4-(Fluoromethyl)dihydrofuran-2(3H)-one; (3S)-4-(Fluoromethyl)oxolan-2-one; (S)-4-(Fluoromethyl)-γ-butyrolactone; (S)-γ-Fluoromethyl-γ-butyrolactone; (S)-4-Fluoromethyl-2-oxotetrahydrofuran; (S)-Tetrahydro-4-(fluoromethyl)-2-furanone; (S)-4-Fluoromethyl-dihydrofuran-2(3H)-one; (S)-4-(Fluoromethyl)tetrahydro-2-furanone
EINECS	Contact for details

Quality Control

Our (S)-4-(Fluoromethyl)-Dihydrofuran-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.