Description

5-Amino-2-(Trifluoromethylsulfonyl)Benzonitrile is a high-value, multi-functional aromatic building block featuring both an amino and a powerful electron-withdrawing trifluoromethanesulfonyl (triflyl) group. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability, lipophilicity, and specific electronic properties are required. It is primarily sought after by R&D and process development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that benefit from the stability imparted by the trifluoromethanesulfonyl moiety.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An essential reagent for exploring new reaction pathways and creating complex molecular architectures in academic and industrial labs.
• Dye and Pigment Intermediate: Utilized in the synthesis of high-performance, light-fast dyes and functional pigments.

Basic Information

Product Name	5-Amino-2-(Trifluoromethylsulfonyl)Benzonitrile
CAS No.	914776-40-2
Molecular Formula	C8H5F3N2O2S
Molecular Weight	250.20 g/mol
Synonyms	2-Amino-5-cyano-α,α,α-trifluorobenzenemethanesulfonic acid; 2-Amino-5-cyanobenzotrifluoride sulfone; 5-Cyano-2-aminobenzotrifluoromethyl sulfone; 2-Cyano-4-aminophenyl trifluoromethyl sulfone; Benzonitrile, 5-amino-2-[(trifluoromethyl)sulfonyl]-; 5-Amino-2-(triflyl)benzonitrile; 2-Trifluoromethanesulfonyl-5-aminobenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Amino-2-(Trifluoromethylsulfonyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.