Description

2-Amino-5-(Trifluoromethylsulfonyl)Benzonitrile is a high-value, multi-functional chemical intermediate characterized by its unique trifluoromethylsulfonyl (SO2CF3) and nitrile (CN) functional groups. This compound matters for its critical role in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where its structure imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethylsulfonyl group for enhanced bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the production of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for transition metal catalysis and organocatalysts due to its electron-withdrawing substituents.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Amino-5-(Trifluoromethylsulfonyl)Benzonitrile
CAS No.	914776-00-4
Molecular Formula	C8H5F3N2O2S
Molecular Weight	250.20 g/mol
Synonyms	2-Amino-5-(trifluoromethanesulfonyl)benzonitrile; 5-(Trifluoromethylsulfonyl)-2-aminobenzonitrile; 2-Cyano-4-(trifluoromethylsulfonyl)aniline; Benzonitrile, 2-amino-5-[(trifluoromethyl)sulfonyl]-; 914776-00-4; 2-Amino-alpha,alpha,α-trifluoro-5-(methylsulfonyl)benzonitrile; 2-Amino-5-(trifluoromethanesulphonyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(Trifluoromethylsulfonyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent lot-to-lot quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.