Description

3-Fluoro-5-Methoxybenzyl Bromide is a high-purity, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and methoxy substituents, makes it an essential reagent for introducing a reactive benzylic handle into complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the preparation of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic and display materials, improving charge transport and thermal stability.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl structures.
• Ligand & Catalyst Development: Employed in the synthesis of specialized phosphine or nitrogen-based ligands for asymmetric catalysis.
• Peptide Mimetics & PROTACs: Useful for the alkylation of amines and thiols in the construction of peptide-like molecules and proteolysis-targeting chimeras (PROTACs).

Basic Information

Product Name	3-Fluoro-5-Methoxybenzyl Bromide
CAS No.	914637-29-9
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-(Bromomethyl)-3-fluoro-5-methoxybenzene; (3-Fluoro-5-methoxyphenyl)methyl Bromide; 3-Fluoro-5-methoxybenzylbromide; α-Bromo-3-fluoro-5-methoxytoluene; 3-Fluoro-5-methyloxybenzyl Bromide; 5-Methoxy-3-fluorobenzyl Bromide; 3-Fluoro-5-methoxy-benzylbromide
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Methoxybenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.