Description

2-Bromo-3-(Trifluoromethyl)Benzonitrile is a versatile and high-value aromatic building block containing both bromine and trifluoromethyl substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications in cross-coupling reactions and as a key intermediate in the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the bromine atom facilitates further functionalization.
• Material Science: Acts as a building block for advanced organic materials, including liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-Bromo-3-(Trifluoromethyl)Benzonitrile
CAS No.	914637-07-3
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	2-Bromo-3-(trifluoromethyl)benzonitrile; 3-Bromo-2-(trifluoromethyl)benzonitrile; 2-(Trifluoromethyl)-3-bromobenzonitrile; Benzonitrile, 2-bromo-3-(trifluoromethyl)-; 914637-07-3; 2-Bromo-alpha,alpha,α-trifluoro-m-toluonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-(Trifluoromethyl)Benzonitrile is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and mass spectrometry, to ensure compliance with industry standards and your specific research requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for full traceability and documentation support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.