Description

3-Methoxy-4-Nitrobenzotrifluoride is a versatile fluorinated aromatic building block, primarily valued for its role as a key intermediate in advanced organic synthesis. Its trifluoromethyl and nitro substituents make it a critical precursor for developing active pharmaceutical ingredients (APIs) and high-performance agrochemicals. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine-containing motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in the development of active pharmaceutical ingredients (APIs) with trifluoromethyl groups.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a key raw material in the manufacture of fluorinated components for electronic displays and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Acts as an intermediate for creating specialized, light-fast dyes and high-performance pigments.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.

Basic Information

Product Name	3-Methoxy-4-Nitrobenzotrifluoride
CAS No.	914636-97-8
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	1-Methoxy-2-nitro-5-(trifluoromethyl)benzene; 4-Nitro-3-methoxybenzotrifluoride; 3-Methoxy-4-nitro-α,α,α-trifluorotoluene; 5-(Trifluoromethyl)-2-nitroanisole; 2-Nitro-5-(trifluoromethyl)anisole; 4-Nitro-3-methoxybenzotrifluoride; 2-Methoxy-5-nitrobenzotrifluoride (isomer check required)
EINECS	Contact for details

Quality Control

Our 3-Methoxy-4-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.