Description

1-Fluoro-2-(Methylsulphonyl)-4-Nitrobenzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring electron-withdrawing nitro and methylsulfonyl groups adjacent to a reactive fluorine atom, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing aryl fluoride and sulfone moieties.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where its structural motifs can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the activated fluorine atom, enabling efficient carbon-carbon and carbon-heteroatom bond formation.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing complex nitro- and sulfone-containing dyes and functional pigments.

Basic Information

Product Name	1-Fluoro-2-(Methylsulphonyl)-4-Nitrobenzene
CAS No.	914636-41-2
Molecular Formula	C7H6FNO4S
Molecular Weight	219.19 g/mol
Synonyms	2-Fluoro-1-methylsulfonyl-4-nitrobenzene; 4-Nitro-2-fluoro-1-(methylsulfonyl)benzene; 1-Fluoro-2-methylsulfonyl-4-nitrobenzene; 2-Fluoro-α,α,α-trifluoro-4-nitrobenzenemethanesulfonate; Benzene, 1-fluoro-2-(methylsulfonyl)-4-nitro-; 914636-41-2; 1-Fluoro-2-methanesulfonyl-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-(Methylsulphonyl)-4-Nitrobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.