Description

3-Chloro-2-Fluoro-5-Nitrobenzotrifluoride is a high-value, multi-functional aromatic building block distinguished by its unique combination of halogen and nitro substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical development. It is primarily sought after by R&D chemists and process engineers in the agrochemical and pharmaceutical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and chlorinated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and nitro groups enhance biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing character.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it a reactive partner for designing novel chemical entities.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized colorants and fluorophores for analytical and industrial applications.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-Nitrobenzotrifluoride
CAS No.	914225-55-1
Molecular Formula	C7H2ClF4NO2
Molecular Weight	243.54 g/mol
Synonyms	2-Fluoro-3-chloro-5-nitrobenzotrifluoride; 1-Chloro-2-fluoro-5-nitro-3-(trifluoromethyl)benzene; Benzene, 1-chloro-2-fluoro-5-nitro-3-(trifluoromethyl)-; 3-Chloro-2-fluoro-5-nitro-α,α,α-trifluorotoluene; 5-Nitro-2-fluoro-3-chlorobenzotrifluoride; 2-Fluoro-3-chloro-α,α,α-trifluoro-5-nitrotoluene
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluoro-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets precise customer specifications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.