Description

(R)-Esmolol Acid is the key chiral intermediate for the synthesis of the ultra-short-acting cardioselective β-1 adrenergic blocker, Esmolol Hydrochloride. This high-purity building block is critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). It is primarily utilized by pharmaceutical manufacturers and advanced research institutions in the development and production of cardiovascular medications and related chiral compounds.

Application

• Primary Intermediate for the synthesis of Esmolol Hydrochloride API.
• Chiral Building Block in pharmaceutical research for β-blocker development.
• Process Chemistry for scaling up the manufacture of cardiovascular drugs.
• Reference Standard for analytical method development and quality control.
• Asymmetric Synthesis studies due to its defined (R)-configuration.

Basic Information

Product Name	(R)-Esmolol Acid
CAS No.	910651-37-5
Molecular Formula	C16H25NO4
Molecular Weight	295.38 g/mol
Synonyms	(R)-Esmolol Acid; (R)-Methyl 4-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate Acid; (R)-ASL-8123 Acid; (R)-Brevibloc Acid; (R)-Esmolol Free Acid; (2R)-Methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoic Acid; (R)-Esmolol Carboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-Esmolol Acid is manufactured under strict quality management systems. Each batch is tested to ensure high chemical and chiral purity, with comprehensive analysis including HPLC for assay and enantiomeric excess (e.e.). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% e.e.
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.