Description

2-Iodo-3-(trifluoromethyl)benzonitrile is a high-value, multi-functional aromatic building block featuring both an iodine substituent and a trifluoromethyl group. This unique structure makes it a critical intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its halogen and fluorine atoms enable key coupling reactions and modulate biological activity. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of drug candidates, particularly in cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances bioavailability and stability.
• Material Science Research: Acts as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent due to the reactivity of the iodine atom for bioconjugation strategies.
• Catalyst & Ligand Development: Useful for synthesizing novel ligands for transition metal catalysts used in fine chemical production.
• Fluorine Chemistry Studies: A valuable compound for research into the effects of fluorine substitution on aromatic systems and reaction pathways.

Basic Information

Product Name	2-Iodo-3-(trifluoromethyl)benzonitrile
CAS No.	905600-49-9
Molecular Formula	C8H3F3IN
Molecular Weight	297.02 g/mol
Synonyms	2-Iodo-3-(trifluoromethyl)benzonitrile; 3-Trifluoromethyl-2-iodobenzonitrile; 2-Iodo-alpha,alpha,α-trifluoro-m-toluonitrile; Benzonitrile, 2-iodo-3-(trifluoromethyl)-; 905600-49-9; 2-Iodo-3-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-3-(trifluoromethyl)benzonitrile is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.