Description

Tetramethylammonium Fluoride is a quaternary ammonium salt that serves as a powerful and versatile source of fluoride ions in organic synthesis. This compound is particularly valued for its solubility in polar aprotic solvents, making it an effective reagent for demanding fluorination and desilylation reactions. It is a critical material for research and development laboratories and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce fluorine atoms or cleave silicon-protecting groups under mild conditions.

Application

• Nucleophilic Fluorination: A key reagent for the synthesis of alkyl fluorides and aryl fluorides via SN2 and aromatic nucleophilic substitution reactions.
• Desilylation Agent: Efficiently removes silyl protecting groups (e.g., TMS, TBS, TIPS) from alcohols, phenols, and carboxylic acids in complex molecule synthesis.
• Catalyst and Promoter: Used as a basic catalyst or promoter in various condensation, polymerization, and rearrangement reactions.
• Electrolyte Component: Investigated for use in specialty electrochemical applications and battery research.
• Pharmaceutical Intermediate: Employed in the synthesis of active pharmaceutical ingredients (APIs) containing fluorine, which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of fluorinated pesticides and herbicides.
• Material Science Research: Applied in the surface modification of materials and the preparation of fluorinated polymers or coatings.

Basic Information

Item	Detail
Product Name	Tetramethylammonium Fluoride
CAS No.	99678-28-1
Molecular Formula	C4H12FN
Molecular Weight	93.14 g/mol
Synonyms	TMAF; Tetramethylammonium fluoride hydrate; N,N,N-Trimethylmethanaminium fluoride; Ammonium, tetramethyl-, fluoride; Fluorotetramethylammonium; Tetramethylazanium fluoride
EINECS	Contact for details

Quality Control

Our Tetramethylammonium Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the rigorous demands of fine chemical synthesis. A Certificate of Analysis (COA) detailing assay, impurity profile, and other critical parameters is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms
Assay (TMAF)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.