Description

14-Bromo 4’-Epi-Daunorubicin Hydrochloride is a chemically modified derivative of the anthracycline antibiotic daunorubicin, distinguished by a bromine substitution at the 14-position and an epimeric configuration at the 4’-sugar position. This structural modification is of significant interest for the development of novel chemotherapeutic agents and as a key synthetic intermediate in pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, chemical synthesis, and biochemical studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel anthracycline-based anticancer agents and prodrugs.
• Biochemical Research: Used as a reference standard or probe in studies investigating DNA intercalation, topoisomerase II inhibition, and mechanisms of drug resistance.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce cardiotoxicity.
• Academic Research: Employed in university and institutional labs for fundamental research in organic synthesis and cancer biology.
• Antitumor Agent Development: Investigated for its potential cytotoxic activity against various cancer cell lines.

Basic Information

Product Name	14-Bromo 4’-Epi-Daunorubicin Hydrochloride
CAS No.	99530-17-3
Molecular Formula	C27H30BrNO10 • HCl
Molecular Weight	645.89 g/mol (for free base, HCl salt adds 36.46 g/mol)
Synonyms	14-Bromo-4'-epidoxorubicin Hydrochloride; 14-Bromo-4'-epidaunorubicin HCl; 4'-Epi-14-bromodaunorubicin Hydrochloride; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-bromo-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione hydrochloride; 14-Br-4'-epi-DNR HCl
EINECS	Contact for details

Quality Control

Our 14-Bromo 4’-Epi-Daunorubicin Hydrochloride is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While typically supplied as a research-grade material, production can be aligned with cGMP standards for advanced preclinical studies upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.