Description

2,2-Difluoro-3-Iodopropionic Acid Fluoride is a highly reactive and versatile fluorinated building block, essential for introducing difluoro and iodo functional groups into complex molecular architectures. Its unique structure makes it a critical intermediate for the synthesis of advanced pharmaceuticals, agrochemicals, and specialty materials. This compound is particularly valuable for researchers and process chemists in the pharmaceutical and fine chemical industries seeking to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and fungicides with enhanced efficacy and environmental profiles.
• Fluorinated Material Precursor: Serves as a monomer or intermediate for creating specialty polymers, liquid crystals, and advanced materials with unique surface properties.
• Cross-Coupling Reactions: The iodine moiety makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex carbon-carbon bonds.
• Radiolabeling Probes: Potential use in the development of iodine-125 or iodine-131 labeled compounds for diagnostic imaging and research.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex, multi-functional organic molecules.

Basic Information

Product Name	2,2-Difluoro-3-Iodopropionic Acid Fluoride
CAS No.	99497-42-4
Molecular Formula	C3H2F3IO2
Molecular Weight	273.95 g/mol
Synonyms	3-Iodo-2,2-difluoropropanoyl Fluoride; 2,2-Difluoro-3-iodopropanoyl Fluoride; Propanoic acid, 3-iodo-2,2-difluoro-, fluoride; Iododifluoropropionyl Fluoride; DFIPF
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-3-Iodopropionic Acid Fluoride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supported by analytical techniques including HPLC, GC, NMR, and IR spectroscopy. Our commitment to quality assurance ensures the material meets the stringent requirements for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and strong acid/organic solvent nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.