Description

3-Chlorofluocinolone Acetonide 21-Acetate is a synthetic corticosteroid derivative, specifically a halogenated and esterified analogue of fluocinolone acetonide. This compound is valued for its potent anti-inflammatory and immunosuppressive activity, making it a critical advanced intermediate in pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers developing next-generation topical corticosteroids and other specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, high-potency topical corticosteroids for dermatological conditions like eczema, psoriasis, and dermatitis.
• Active Pharmaceutical Ingredient (API) Research: Serves as a precursor or model compound in medicinal chemistry research for developing new anti-inflammatory drugs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method development of steroid-based pharmaceuticals.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor interactions and the mechanisms of steroid action at the cellular level.

Basic Information

Product Name	3-Chlorofluocinolone Acetonide 21-Acetate
CAS No.	99339-99-8
Molecular Formula	C26H30ClFO7
Molecular Weight	509.0 g/mol (approx.)
Synonyms	3-Chloro-6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-acetate; 3-Chloro-6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, 21-acetate; Fluocinolone Acetonide 3-Chloro-21-Acetate; 3-Chlorofluocinolone Acetonide Acetate; 21-Acetoxy-3-chloro-6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
EINECS	Contact for details

Quality Control

Our 3-Chlorofluocinolone Acetonide 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.