Description

Nebivolol CAS NO 99200-09-6 is a highly selective β-1 adrenergic receptor blocker, recognized for its unique vasodilatory properties. This active pharmaceutical ingredient (API) is critical for the formulation of cardiovascular medications, offering a favorable hemodynamic profile. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for hypertension and heart failure.

Application

• Pharmaceutical API: Primary active ingredient in antihypertensive tablet formulations.
• Cardiovascular Research: Key compound for studying β-blocker mechanisms and vascular reactivity in preclinical models.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of branded nebivolol medications.
• Dosage Form Development: Used in R&D for developing novel delivery systems such as controlled-release tablets.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing.
• Clinical Trial Material: Supply for manufacturing investigational medicinal products (IMPs) for clinical studies.

Basic Information

Product Name	Nebivolol
CAS No.	99200-09-6
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	Nebivolol Hydrochloride; Bystolic; R 65-747; (1RS,1'RS)-1,1'-[(2RS,2'SR)-Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol; 1,1'-[Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol; DL-Nebivolol; (±)-Nebivolol
EINECS	Contact for details

Quality Control

Our Nebivolol is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is tested to ensure compliance with in-house specifications aligned with major pharmacopoeial standards (e.g., USP, EP). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee supply reliability and regulatory readiness.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.