Description

S-(-)-Bisoprolol is the pharmacologically active enantiomer of the β-blocker bisoprolol, characterized by its high stereochemical purity. This compound is critical for the development of enantiomerically pure cardiovascular pharmaceuticals, offering superior receptor selectivity and potentially reduced side-effect profiles compared to racemic mixtures. It is an essential chiral intermediate and active pharmaceutical ingredient (API) for manufacturers of advanced antihypertensive and antianginal medications targeting global markets.

Application

• Primary Active Pharmaceutical Ingredient (API) in enantiomerically pure cardiovascular drugs.
• Chiral intermediate for the synthesis of advanced β-1-adrenergic receptor blockers.
• Key component in research and development of novel stereoselective therapies for hypertension and angina pectoris.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Used in preclinical and clinical studies investigating the pharmacokinetics of the S-enantiomer.

Basic Information

Item	Detail
Product Name	S-(-)-Bisoprolol
CAS No.	99103-03-4
Molecular Formula	C18H31NO4
Molecular Weight	325.44 g/mol
Synonyms	(S)-Bisoprolol; (-)-Bisoprolol; S-Bisoprolol; Bisoprolol S-enantiomer; (S)-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol; Concor (enantiomer); Zebeta (enantiomer)
EINECS	Contact for details

Quality Control

Our S-(-)-Bisoprolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Maximum Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.