Description

N,n-Dimethyladriamycin-14-Valerate CAS NO 98910-80-6 is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin (Adriamycin). This compound is significant for its role as a key intermediate in pharmaceutical research and development, particularly in the synthesis of novel chemotherapeutic agents and targeted drug conjugates. It is primarily needed by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery, aiming to improve therapeutic efficacy and reduce systemic toxicity.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing advanced doxorubicin analogs and prodrugs.
• Oncology Research: Used in preclinical studies to investigate structure-activity relationships (SAR) and develop new anticancer therapies.
• Drug Conjugate Development: Serves as a payload or linker-payload component in antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Biochemical Research: Employed as a tool compound to study mechanisms of action, DNA intercalation, and topoisomerase II inhibition.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for anthracycline-based active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	N,n-Dimethyladriamycin-14-Valerate
CAS No.	98910-80-6
Molecular Formula	C₃₂H₃₇NO₁₂
Molecular Weight	627.64 g/mol
Synonyms	14-O-(3-Carboxy-1-oxopropyl)-4-demethoxy-7-O-[2,6-dideoxy-4-O-(2,3,6-trideoxy-3-amino-α-L-lyxo-hexopyranosyl)-α-L-lyxo-hexopyranosyl]adriamycinone; Doxorubicin-14-valerate, N,N-dimethyl-; 4-Demethoxydaunorubicin-14-valerate, N,N-dimethyl-; AD 32 Valerate; Valrubicin derivative; N,N-Dimethyldoxorubicin-14-valerate; N,N-Dimethyl-14-valeryldoxorubicin
EINECS	Contact for details

Quality Control

Our N,n-Dimethyladriamycin-14-Valerate is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a dry environment to ensure long-term stability.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.