Description

Halobetasol is a synthetic corticosteroid belonging to the class of ultra-high potency topical glucocorticoids. It is a critical active pharmaceutical ingredient (API) valued for its potent anti-inflammatory and immunosuppressive properties. This compound is primarily utilized by pharmaceutical manufacturers in the development and production of prescription-strength topical formulations for treating severe dermatological conditions.

Application

• Topical Corticosteroid Formulations: Primary API in creams, ointments, and lotions for treating severe skin inflammation.
• Psoriasis Treatment: Key ingredient in medications for managing plaque psoriasis and other steroid-responsive dermatoses.
• Eczema and Dermatitis Therapy: Used in formulations to control symptoms of atopic dermatitis, contact dermatitis, and other eczematous disorders.
• Lichen Planus and Lichen Simplex Chronicus: Incorporated into therapies for these chronic, itchy skin conditions.
• Pharmaceutical Intermediates: Serves as a starting material or intermediate for the synthesis of related corticosteroid derivatives.
• Veterinary Dermatology: Used in topical preparations for managing inflammatory skin conditions in animals under veterinary supervision.

Basic Information

Product Name	Halobetasol
CAS No.	98651-66-2
Molecular Formula	C25H31ClF3O5
Molecular Weight	503.96 g/mol
Synonyms	Halobetasol Propionate; (6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Ultravate (Brand Name); CGP 14458; SQ-18566; Halobetasol Propionate (USP); Halobetasolum Propionas
EINECS	Contact for details

Quality Control

Our Halobetasol is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet or exceed relevant pharmacopeial standards, including USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs where applicable. Each batch is supported by a detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles, ensuring compliance for GMP pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.