Description

Metoprolol Succinate CAS NO 98418-47-4 is the succinate salt form of metoprolol, a cardioselective β-1 adrenergic receptor blocker. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy, stability, and batch-to-batch consistency of finished pharmaceutical products. It is primarily required by pharmaceutical manufacturers for the formulation of extended-release tablets used in the management of hypertension, angina pectoris, and heart failure.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of extended-release oral solid dosage forms (tablets).
• Cardiovascular Therapeutics: Formulation of medications for the treatment of hypertension (high blood pressure).
• Angina Management: Used in drugs for the long-term management of chronic stable angina.
• Heart Failure Therapy: A key component in certain heart failure treatment regimens to improve survival and reduce hospitalizations.
• Generic Drug Production: Sourcing for manufacturers of bioequivalent generic versions of branded metoprolol succinate medications.
• Clinical Research: Serves as a reference standard or raw material in pharmaceutical R&D and clinical trials.

Basic Information

Product Name	Metoprolol Succinate
CAS No.	98418-47-4
Molecular Formula	C34H56N2O8
Molecular Weight	620.82 g/mol
Synonyms	Metoprolol Succinate Salt; Metoprolol Hydrogen Succinate; (±)-Metoprolol Succinate; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol Succinate; Succinic acid compound with metoprolol (1:1); Toprol-XL (Brand Name Equivalent API); Lopressor Succinate; CGP 2175
EINECS	Contact for details

Quality Control

Our Metoprolol Succinate is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopoeial standards such as USP, EP, and BP monographs. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.