Description

2,4,5-Trifluorobenzonitrile is a high-value fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its unique trifluorinated pattern makes it a critical intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by manufacturers of specialty materials like liquid crystals and electronic chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for high-performance displays (LCDs).
• Organic Electronic Materials: Employed in the development of organic semiconductors, electron-transport materials, and other components for OLEDs and photovoltaic cells.
• Cross-Coupling Reactions: The nitrile and halogen groups make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to build complex biaryl systems.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new fluorination chemistry and creating novel molecular libraries.

Basic Information

Product Name	2,4,5-Trifluorobenzonitrile
CAS No.	98349-22-5
Molecular Formula	C7H2F3N
Molecular Weight	157.09 g/mol
Synonyms	2,4,5-Trifluorobenzene carbonitrile; 2,4,5-Trifluorophenyl cyanide; Benzonitrile, 2,4,5-trifluoro-; 98349-22-5; 2,4,5-Trifluorobenzonitrile; 2,4,5-Trifluoro cyanobenzene
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluorobenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, and our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.