Description

3',6'-Dihydroxy-3',5'-Diepidaunorubicin is a chemically modified derivative of the anthracycline antibiotic daunorubicin, characterized by its unique epoxide and dihydroxy functional groups. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a key intermediate or active pharmaceutical ingredient (API) in novel oncology therapeutics. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the synthesis and evaluation of next-generation anticancer agents and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel anthracycline-based chemotherapeutic agents.
• Oncology Research: Used as a reference standard or experimental compound in biochemical and pharmacological studies to investigate mechanisms of action, cytotoxicity, and DNA intercalation.
• API Development: Employed in the research and development of new Active Pharmaceutical Ingredients (APIs) targeting various cancer cell lines.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to modify the daunorubicin scaffold to enhance efficacy or reduce side effects like cardiotoxicity.
• Analytical Standard: Used as a high-purity standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Product Name	3',6'-Dihydroxy-3',5'-Diepidaunorubicin
CAS No.	98103-10-7
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	3',6'-Dihydroxy-3',5'-diepidaunomycin; 3',6'-Dihydroxydaunorubicin 3',5'-epoxide; Daunorubicin derivative, 3',6'-dihydroxy-3',5'-epoxy; 4-Demethoxy-3',6'-dihydroxy-3',5'-diepidaunorubicin; (1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside 3',5'-epoxide
EINECS	Contact for details

Quality Control

Our 3',6'-Dihydroxy-3',5'-Diepidaunorubicin is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to strict quality management protocols to support our clients' needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere such as argon or nitrogen in a desiccated environment. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.