Description

2-(Difluoromethoxy)-1-Fluoro-4-Nitro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy and nitro substituents make it a versatile intermediate for constructing complex molecules with tailored electronic and physical properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and liquid crystals, where the fluorinated aromatic core contributes to thermal stability and unique optical properties.
• Organic Electronics: Employed in the development of organic semiconductors and electron-transport materials due to the electron-withdrawing nitro and difluoromethoxy groups.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry for introducing fluorinated motifs and exploring novel structure-activity relationships (SAR).

Basic Information

Product Name	2-(Difluoromethoxy)-1-Fluoro-4-Nitro-Benzene
CAS No.	97963-50-3
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	1-Fluoro-2-(difluoromethoxy)-4-nitrobenzene; 4-Nitro-2-(difluoromethoxy)fluorobenzene; 2-(Difluoromethoxy)-1-fluoro-4-nitrobenzene; Benzene, 2-(difluoromethoxy)-1-fluoro-4-nitro-; 97963-50-3; 1-Fluoro-4-nitro-2-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-1-Fluoro-4-Nitro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.