Description

4-Demethyl-6-o-Methyldoxorubicin is a semi-synthetic anthracycline derivative, representing a significant structural analog of the potent anticancer agent doxorubicin. This compound is valued for its role in advanced pharmaceutical research, particularly in the study of structure-activity relationships and the development of novel chemotherapeutic agents with potentially improved efficacy or reduced side-effect profiles. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of new anthracycline-based anticancer drugs.
• Oncology Drug Discovery: Used to investigate mechanisms of action, DNA intercalation, and topoisomerase II inhibition to develop next-generation chemotherapeutics.
• Biochemical Studies: Employed in in vitro and in vivo studies to evaluate cytotoxicity, pharmacokinetics, and metabolic pathways.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Academic Research: Utilized in university and institutional labs for fundamental research on anthracycline antibiotics and cancer biology.

Basic Information

Product Name	4-Demethyl-6-o-Methyldoxorubicin
CAS No.	97777-78-1
Molecular Formula	C27H29NO10
Molecular Weight	527.52 g/mol
Synonyms	4-Demethyl-6-O-methyldoxorubicin; 6-O-Methyl-4-demethyldoxorubicin; 4-Deoxy-4-demethyl-6-O-methyladriamycin; 4-Demethoxy-6-O-methyldoxorubicin; Doxorubicin, 4-demethyl-6-O-methyl-; (8S,10S)-8-Glycoloyl-10-[(2S,4S,5S,6S)-4-methoxy-5-[(2S,4S,5S,6S)-tetrahydro-6-methyl-5-hydroxy-2H-pyran-2-yl]oxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our 4-Demethyl-6-o-Methyldoxorubicin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.