Description

Mithramycin A CAS NO 97666-60-9 is a potent aureolic acid-type polyketide antibiotic isolated from *Streptomyces* species. This compound is of significant interest in biochemical and pharmaceutical research due to its specific mechanism of action as an inhibitor of Sp1 transcription factor and its ability to intercalate with DNA. It is primarily utilized by research institutions and pharmaceutical developers engaged in oncology research, molecular biology studies, and the investigation of gene expression regulation.

Application

• Oncology and Cancer Research: Used as a biochemical tool to study transcription inhibition, apoptosis, and as a reference standard in anti-cancer drug discovery programs.
• Molecular Biology: Serves as a selective inhibitor in studies of gene expression, particularly those involving the GC-rich promoter regions targeted by the Sp1 family of transcription factors.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Mechanism Studies: Applied in research to elucidate pathways of DNA binding, chromatin remodeling, and transcriptional regulation.
• Cell Culture and *In Vitro* Assays: Utilized in cell-based assays to investigate its effects on proliferation and differentiation in various cell lines.

Basic Information

Item	Detail
Product Name	Mithramycin A
CAS No.	97666-60-9
Molecular Formula	C52H76O24
Molecular Weight	1085.15 g/mol
Synonyms	Plicamycin; Aureolic Acid; Mithracin; Mitramycin; LA 7017; NSC 24559; Antibiotic LA 7017; 6-[6-Deoxy-2-O-(2,6-dideoxy-β-D-ribo-hexopyranosyl)-β-D-galactopyranosyl]oxy-4-(dimethylamino)-10-hydroxy-3a,5,5a,6-tetrahydro-3H-8,9-dioxa-cyclopenta[a]naphthalene-1,7-dione
EINECS	Contact for details

Quality Control

Our Mithramycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.