Description

3-(Difluoromethoxy)Benzonitrile is a versatile fluorinated aromatic nitrile building block, essential for introducing the difluoromethoxy group into complex molecular architectures. Its value lies in enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs) with enhanced metabolic stability and lipophilicity. This high-purity intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where the difluoromethoxy moiety improves biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Polymer Modification: Incorporated into specialty polymers to alter thermal stability, chemical resistance, and optical properties.
• Organic Electronics: Building block for electron-transport materials and emissive layers in OLED devices.
• Chemical Research & Development: A valuable reagent for exploring new fluorination chemistry and creating compound libraries for screening.

Basic Information

Product Name	3-(Difluoromethoxy)Benzonitrile
CAS No.	97582-88-2
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	m-(Difluoromethoxy)benzonitrile; 3-(Difluoromethoxy)phenyl cyanide; Benzonitrile, 3-(difluoromethoxy)-; 1-Cyano-3-(difluoromethoxy)benzene; α,α-Difluoro-m-methoxybenzonitrile; DFMB (abbrev.); 97582-88-2; 3-DFMOB
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.