Description

A-Hydroxy Tamoxifen is a key active metabolite of the widely used antiestrogen drug Tamoxifen. This compound is of significant interest in pharmaceutical research and development, particularly in the study of breast cancer therapeutics and endocrine-related pathways. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A crucial synthetic precursor in the production of Tamoxifen and related therapeutic agents.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate estrogen receptor modulation, drug metabolism, and mechanisms of action.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the efficacy and safety profile of Tamoxifen therapy.
• Diagnostic Development: Potential use in the development of diagnostic assays and kits for therapeutic drug monitoring.

Basic Information

Product Name	A-Hydroxy Tamoxifen
CAS No.	97151-02-5
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	4-Hydroxytamoxifen; (Z)-4-Hydroxytamoxifen; Afimoxifene; ICI 79280; Metabolite E; Endoxifen; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-4-ol; trans-4-Hydroxytamoxifen
EINECS	Contact for details

Quality Control

Our A-Hydroxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.