Description

(D-Tyr5)-Leuprolide is a synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH). This compound is a key intermediate and research-grade standard used in the development and quality control of advanced pharmaceutical products. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide-based therapeutics. The material is critical for studies involving hormone regulation and the synthesis of specialized peptide conjugates.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and intermediate in the synthesis of novel GnRH analogs and peptide-drug conjugates.
• Quality Control & Analytical Standards: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods to ensure the identity and purity of commercial leuprolide-based APIs.
• Biochemical Research: Employed in academic and industrial laboratories to study GnRH receptor binding, hormone signaling pathways, and structure-activity relationships (SAR).
• Process Development: Acts as a key building block in the scale-up and optimization of solid-phase or solution-phase peptide synthesis processes.
• Preclinical Studies: Utilized in the formulation and testing of experimental therapeutic agents targeting hormone-dependent conditions.

Basic Information

Product Name	(D-Tyr5)-Leuprolide
CAS No.	112710-57-3
Molecular Formula	C59H84N16O12
Molecular Weight	1209.4 g/mol
Synonyms	5-D-Tyrosyl-leuprolide; Leuprolide (5-D-Tyr) analog; [D-Tyr5]-Leuprolide; GnRH analog (D-Tyr5); pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; (Des-Gly10, D-Leu6, Pro-NHEt9)-LHRH (5-D-Tyr); Luteinizing Hormone-Releasing Hormone Fragment (5-D-Tyr)
EINECS	Contact for details

Quality Control

Our (D-Tyr5)-Leuprolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 95.0% (Total Peptide Content)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.