Description

Endoxifen is a potent and selective estrogen receptor modulator (SERM) and a key active metabolite of tamoxifen. This compound is of significant interest in advanced pharmaceutical research and development due to its enhanced therapeutic profile and reduced metabolic variability compared to its parent drug. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development organizations engaged in oncology, endocrinology, and novel drug delivery systems.

Application

• Pharmaceutical Active Ingredient (API): Core component in the development and formulation of next-generation breast cancer therapeutics.
• Clinical Research: Used as a reference standard and investigational agent in pharmacokinetic and pharmacodynamic studies.
• Drug Discovery: A critical compound for studying estrogen receptor pathways and developing new SERM-based treatments for various hormone-dependent conditions.
• Biochemical Research: Employed in vitro and in vivo to investigate mechanisms of action related to estrogen receptor alpha (ERα) modulation.
• Analytical Standard: Serves as a high-purity standard for quality control and assay development in analytical laboratories.

Basic Information

Item	Details
Product Name	Endoxifen
CAS No.	112093-28-4
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	Z-Endoxifen; (Z)-4-Hydroxy-N-desmethyltamoxifen; N-Desmethyl-4-hydroxytamoxifen; FC-1271a; Major active metabolite of Tamoxifen; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-4-ol
EINECS	Contact for details

Quality Control

Our Endoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.