Description

(R)-Bicalutamide CAS NO 113299-40-4 is the pharmacologically active enantiomer of the non-steroidal anti-androgen bicalutamide. This high-purity chiral intermediate is critical for the development and manufacturing of advanced pharmaceutical compounds targeting androgen receptor pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in oncology and endocrinology. The compound's stereochemical purity is essential for ensuring targeted biological activity and efficacy in final drug formulations.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of enantiomerically pure bicalutamide and related anti-androgen therapies.
• Oncology Research: Used in preclinical and clinical research for prostate cancer treatment, studying the specific effects of the (R)-enantiomer.
• Pharmacology Studies: Serves as a reference standard and tool compound for investigating androgen receptor binding and antagonism.
• Process Development: Employed in the development and scale-up of asymmetric synthesis routes for pharmaceutical manufacturing.
• Analytical Standard: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.
• Drug Discovery: A starting material or intermediate in the discovery of new chemical entities targeting hormone-dependent conditions.

Basic Information

Product Name	(R)-Bicalutamide
CAS No.	113299-40-4
Molecular Formula	C18H14F4N2O4S
Molecular Weight	430.38 g/mol
Synonyms	(R)-Bicalutamide; (R)-Enantiomer of Bicalutamide; (R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; (R)-Casodex; Bicalutamide R-Isomer; (R)-ICI 176334; (R)-ICI-176334; (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
EINECS	Contact for details

Quality Control

Our (R)-Bicalutamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (typically >99.0%) and identity confirmation by IR and MS. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.