Description

Minamestane is a potent and selective non-steroidal aromatase inhibitor, a key compound in advanced pharmaceutical research and development. Its primary value lies in its ability to effectively block the aromatase enzyme, which is crucial for the biosynthesis of estrogens. This makes it an essential intermediate and active pharmaceutical ingredient (API) for researchers and manufacturers in the oncology and endocrinology sectors, particularly for developing treatments for hormone-dependent conditions.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced aromatase inhibitor drugs.
• Oncology Research: Used in preclinical and clinical studies targeting hormone-responsive cancers, such as breast cancer.
• Endocrinology Studies: Applied in research to understand and modulate estrogen biosynthesis pathways.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in laboratories.
• API Manufacturing: Incorporated into the final formulation of finished dosage forms for therapeutic use.
• Biochemical Assay Development: Employed in creating in-vitro tests to screen for aromatase inhibitory activity.

Basic Information

Product Name	Minamestane
CAS No.	105051-87-4
Molecular Formula	C20H28O2
Molecular Weight	300.44 g/mol
Synonyms	1-Methyl-1,4-androstadiene-3,17-dione; 1-Methyl-1,4-androstadiene-3,17-dione; Exemestane Impurity; Exemestane Related Compound A; Aromasin Impurity; CCG-202768; UNII-4TI2C8Q82L
EINECS	Contact for details

Quality Control

Our Minamestane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.