Description

Nafoxidine CAS NO 1845-11-0 is a selective estrogen receptor modulator (SERM) with significant research and pharmaceutical applications. This compound is valued for its potent anti-estrogenic properties, making it a critical tool in the study of hormone-dependent biological pathways. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and fine chemical manufacturers engaged in the development of therapeutic agents.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel SERMs and hormone therapies.
• Biochemical Research: Used as a molecular probe to study estrogen receptor (ER) signaling, binding affinity, and antagonist mechanisms in vitro and in vivo.
• Oncology Research: Investigation of potential applications in hormone-dependent cancers, such as breast cancer, due to its anti-estrogenic activity.
• Academic Studies: A key compound in university and institutional research focused on endocrinology, reproductive biology, and cancer biology.
• Fine Chemical Synthesis: Serves as a sophisticated building block for the synthesis of more complex, targeted therapeutic molecules.
• Reference Material: Used for analytical method development, validation, and quality control in laboratories requiring high-purity standards.

Basic Information

Item	Detail
Product Name	Nafoxidine
CAS No.	1845-11-0
Molecular Formula	C25H27NO4
Molecular Weight	405.49 g/mol
Synonyms	1-[2-[4-[(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine; Nafoxidine Hydrochloride; U-11,100A; U-11100A; NSC-70735; Nafoxidina; Nafoxidin
EINECS	Contact for details

Quality Control

Our Nafoxidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.