Description

Fadrozole Hydrochloride is a potent, selective, and non-steroidal aromatase inhibitor used in pharmaceutical research and development. This compound is critical for studies targeting estrogen-dependent conditions, offering a valuable tool for biochemical and pharmacological investigations. It is primarily utilized by pharmaceutical companies, academic research institutions, and contract research organizations (CROs) engaged in oncology, endocrinology, and drug discovery programs.

Application

• Pharmaceutical Research: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of aromatase inhibitors for cancer therapy.
• Oncology Studies: Used in preclinical and clinical research for hormone-dependent cancers, such as breast cancer, to study tumor growth inhibition.
• Biochemical Assays: Employed as a specific inhibitor in enzymatic assays to study the function and kinetics of the aromatase enzyme (CYP19).
• Endocrine Disorder Research: Applied in research models for conditions like endometriosis and gynecomastia where estrogen modulation is therapeutic.
• Veterinary Medicine: Investigated for use in treating estrogen-dependent conditions in animals.
• Academic & Contract Research: A fundamental compound for university labs and CROs conducting basic science and drug discovery projects.

Basic Information

Product Name	Fadrozole Hydrochloride
CAS No.	102676-31-3
Molecular Formula	C14H13FN4•HCl
Molecular Weight	292.74 g/mol
Synonyms	Fadrozole HCl; CGS 16949A; 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride; Afema (brand name); CGS-16949A; Aromatase Inhibitor CGS 16949A; UNII-9K8806I7S5
EINECS	Contact for details

Quality Control

Our Fadrozole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.