Description

(S)-Bicalutamide CAS NO 113299-38-0 is the pure (S)-enantiomer of the non-steroidal antiandrogen bicalutamide, offering targeted biological activity for advanced research and development. This high-purity chiral compound is critical for studies requiring stereochemical specificity, particularly in the investigation of androgen receptor interactions. It is an essential intermediate and reference standard for pharmaceutical R&D laboratories focused on oncology, endocrinology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for quality control and analytical method development in API manufacturing.
• Biomedical Research: A key tool for in vitro and in vivo studies investigating the specific pharmacological profile and metabolism of the (S)-enantiomer.
• Mechanistic Studies: Employed to elucidate stereospecific binding kinetics and downstream effects on androgen receptor signaling pathways.
• Process Chemistry & Intermediate: Serves as a critical chiral building block in the synthetic route for advanced pharmaceutical compounds.
• Analytical Method Development: Utilized for developing and validating chiral separation methods (e.g., HPLC, CE) for bicalutamide enantiomers.
• Preclinical Development: Supports toxicology, pharmacokinetics (PK), and pharmacodynamics (PD) studies for new drug candidates.

Basic Information

Product Name	(S)-Bicalutamide
CAS No.	113299-38-0
Molecular Formula	C18H14F4N2O4S
Molecular Weight	430.38 g/mol
Synonyms	(S)-Bicalutamide; (S)-Enantiomer of Bicalutamide; (S)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; (S)-Casodex; Bicalutamide S-Isomer; (S)-ICI 176,334; (S)-4'-Cyano-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide
EINECS	Contact for details

Quality Control

Our (S)-Bicalutamide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.