Description

Nafoxidine CAS NO 1847-63-8 is a selective estrogen receptor modulator (SERM) and a well-characterized research chemical. It serves as a crucial pharmacological tool for studying estrogen receptor interactions and related biological pathways. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on endocrinology, oncology, and drug discovery.

Application

• Pharmaceutical Research & Development: A key reference standard and active compound in the study of estrogen receptor biology and the development of novel SERMs.
• Biochemical Assay Development: Used as a ligand in competitive binding assays (e.g., ERα/ERβ) to screen and characterize new chemical entities.
• Academic & Preclinical Studies: Employed in in vitro and in vivo models to investigate hormonal regulation, breast cancer mechanisms, and metabolic pathways.
• Reference Standard for QC/QA: Serves as a high-purity analytical standard for method validation, impurity profiling, and quality control of related pharmaceutical substances.
• Chemical Intermediate: Can be used in the synthesis of more complex molecules or labeled derivatives for tracer studies.

Basic Information

Product Name	Nafoxidine
CAS No.	1847-63-8
Molecular Formula	C29H35NO3
Molecular Weight	445.60 g/mol
Synonyms	1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]ethyl]pyrrolidine; Nafoxidine Hydrochloride (salt form); U-11,100A; NSC-70735; Upjohn 11100A; Estrogen antagonist U-11100A
EINECS	217-426-9

Quality Control

Our Nafoxidine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, MS), to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.