Description

Tamoxifen Methiodide is a quaternary ammonium salt derivative of the selective estrogen receptor modulator (SERM) Tamoxifen. This compound is a critical research-grade chemical and pharmaceutical intermediate used in advanced biochemical studies and drug development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) working on oncology therapeutics and hormone-related research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel Tamoxifen analogs and related therapeutic agents for clinical research.
• Biochemical Research: Used as a potent, membrane-impermeable estrogen receptor antagonist in cell biology and molecular pharmacology studies.
• Mechanism of Action Studies: Employed to investigate estrogen receptor signaling pathways, particularly in breast cancer cell lines, due to its charged nature limiting intracellular uptake.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Clinical Research: Facilitates fundamental research in endocrinology, oncology, and drug resistance mechanisms.
• Process Development: Used in scaling up and optimizing synthetic routes for Tamoxifen-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Tamoxifen Methiodide
CAS No.	107256-99-5
Molecular Formula	C27H31INO
Molecular Weight	536.45 g/mol
Synonyms	Tamoxifen Methyl Iodide; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanaminium Iodide; ICI 47699 Methiodide; trans-Tamoxifen Methiodide; N,N-Dimethyl-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]ethanaminium Iodide; Tamoxifen Quaternary Ammonium Salt; Tamoxifen Methyl Iodide Salt
EINECS	Contact for details

Quality Control

Our Tamoxifen Methiodide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.