Description

Tamoxifen is a selective estrogen receptor modulator (SERM) of the triphenylethylene class, widely recognized for its pivotal role in oncology and research. This compound is essential for the treatment and management of hormone receptor-positive breast cancer, functioning as a competitive antagonist of estrogen at its receptor site. It serves as a critical active pharmaceutical ingredient (API) for pharmaceutical manufacturers, a key reference standard for analytical laboratories, and a fundamental research chemical for studying endocrine pathways and cancer biology.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulations for the treatment of estrogen receptor-positive (ER+) breast cancer in pre- and post-menopausal women.
• Research & Development: A vital tool in biomedical research for studying estrogen receptor biology, mechanisms of cancer cell proliferation, and resistance pathways.
• Reference Standard: Used in quality control (QC) and analytical laboratories as a high-purity standard for HPLC, LC-MS, and other chromatographic methods to ensure product identity and assay.
• Preclinical Studies: Employed in *in vitro* and *in vivo* studies to evaluate efficacy, pharmacokinetics, and toxicology of SERM-based therapies.
• Chemical Intermediate: Serves as a key synthetic intermediate for the production of related therapeutic compounds and metabolites in advanced pharmaceutical synthesis.

Basic Information

Product Name	Tamoxifen
CAS No.	15917-50-7
Molecular Formula	C26H29NO
Molecular Weight	371.52 g/mol
Synonyms	(Z)-Tamoxifen; Tamoxifen Citrate (base); ICI 46474; Nolvadex; Soltamox; Trans-Tamoxifen; 1-(4-[2-(Dimethylamino)ethoxy]phenyl)-1,2-diphenyl-1-butene; 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
EINECS	240-094-7

Quality Control

Our Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive; ensure containers are kept in original packaging or opaque storage until use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.