Description

18-Hydroxycortisone is a synthetic corticosteroid derivative, a key intermediate in the synthesis of more complex steroid-based pharmaceuticals. This compound matters for its role in research and development, enabling the creation of novel therapeutic agents with targeted biological activity. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in steroid chemistry and endocrinology research.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced corticosteroid drugs and other bioactive steroid molecules.
• Biochemical Research: Used as a reference standard or experimental compound in studies investigating corticosteroid metabolism, enzyme activity (e.g., 11β-hydroxysteroid dehydrogenase), and receptor interactions.
• Metabolite Standard: Serves as an analytical standard in bioanalytical methods (LC-MS, HPLC) for the detection and quantification of steroid metabolites in biological samples.
• Process Development: Employed in the development and scale-up of synthetic routes for steroid-based active pharmaceutical ingredients (APIs).
• Academic & Contract Research: Utilized in university and CRO settings for fundamental research in medicinal chemistry and endocrinology.

Basic Information

Product Name	18-Hydroxycortisone
CAS No.	96737-55-2
Molecular Formula	C₂₁H₂₈O₆
Molecular Weight	376.45 g/mol
Synonyms	11β,17α,21-Trihydroxypregn-4-ene-3,18,20-trione; 18-Oxocortisol; 18-Oxocorticosterone; 18-Hydroxycorticosterone; 18-Hydroxy-11-dehydrocorticosterone; 18-Oxo-11-dehydrocorticosterone; 18-Hydroxycortisone acetate (related ester)
EINECS	Contact for details

Quality Control

Our 18-Hydroxycortisone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA) that includes results from HPLC, NMR, and other relevant spectroscopic and chromatographic methods. Specifications are aligned with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.