Description

2,4,6-Trifluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters as a key precursor for introducing the trifluoromethylphenyl moiety into complex molecules, significantly altering their electronic properties, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty materials like liquid crystals and polymers.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Polymer & Material Science: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and optical properties.
• Organic Electronics: Utilized in the synthesis of electron-deficient units for organic semiconductors and non-fullerene acceptors in organic photovoltaics (OPVs).
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl systems.

Basic Information

Product Name	2,4,6-Trifluorobenzonitrile
CAS No.	96606-37-0
Molecular Formula	C7H2F3N
Molecular Weight	157.09 g/mol
Synonyms	2,4,6-Trifluorobenzene carbonitrile; 2,4,6-Trifluorophenyl cyanide; Benzonitrile, 2,4,6-trifluoro-; 2,4,6-Trifluorobenzonitrile; 96606-37-0; α,α,α-Trifluoroisophthalonitrile (less common); 2,4,6-Trifluorocyanobenzene
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	48 - 52 °C
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.