Description

4-Demethyl-6-Deoxydoxorubicin is a key synthetic intermediate and structural analog of the potent anthracycline antibiotic, doxorubicin. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel chemotherapeutic agents and for studying structure-activity relationships. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel anthracycline-based anticancer drugs and their derivatives.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating the mechanism of action, metabolism, and resistance pathways of anthracycline antibiotics.
• Structure-Activity Relationship (SAR) Studies: Essential for modifying the doxorubicin scaffold to develop new compounds with potentially improved efficacy or reduced side effects.
• Academic and Contract Research: Serves as a starting material for synthetic chemistry projects in university labs and contract research organizations (CROs) focused on medicinal chemistry.
• Analytical Standard: Employed as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and impurity profiling of related pharmaceutical substances.

Basic Information

Product Name	4-Demethyl-6-Deoxydoxorubicin
CAS No.	96597-11-4
Molecular Formula	C₂₆H₂₉NO₁₀
Molecular Weight	515.51 g/mol
Synonyms	6-Deoxy-4-demethyldoxorubicin; 4-Demethyl-6-deoxyadriamycin; 4-DM-6-DOX; 4-Demethyldaunorubicinone 6-deoxy derivative; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our 4-Demethyl-6-Deoxydoxorubicin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.