Description

Butanamide, n-[3-Acetyl-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenyl]-, Monohydrochloride, (S)- is a high-purity, single-enantiomer pharmaceutical intermediate with significant commercial importance. This compound is critical for ensuring the quality and efficacy of advanced active pharmaceutical ingredients (APIs) in the cardiovascular therapeutic area. It is primarily required by pharmaceutical manufacturers and advanced R&D facilities engaged in the synthesis of sophisticated chiral drugs.

Application

• Key Intermediate for Cardiovascular APIs: Serves as a critical building block in the synthesis of specific β-adrenergic blocking agents.
• Pharmaceutical R&D: Used in process development and scale-up studies for new chemical entities (NCEs) targeting adrenergic receptors.
• Chiral Synthesis: Employed in asymmetric synthesis routes where the (S)-enantiomer configuration is essential for biological activity.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory testing of finished APIs.
• Process Chemistry Optimization: Utilized to develop and refine efficient, scalable manufacturing processes for complex molecules.

Basic Information

Item	Details
Product Name	Butanamide, n-[3-Acetyl-4-[2-Hydroxy-3-[(1-Methylethyl)Amino]Propoxy]Phenyl]-, Monohydrochloride, (S)-
CAS No.	96450-12-3
Molecular Formula	C20H31N2O4•HCl
Molecular Weight	400.94 g/mol
Synonyms	(S)-N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butyramide Monohydrochloride; (S)-N-[3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]butyramide Hydrochloride; (S)-Bucumolol Hydrochloride; (S)-Bucumolol HCl; (S)-1-(2-Hydroxy-3-isopropylaminopropoxy)-n-butyryl-3-acetamidobenzene Hydrochloride; (S)-KU-495 Hydrochloride; (S)-Bucumarol Hydrochloride
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediate is produced under strict quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for API synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a low-humidity environment and opened under dry, inert conditions when necessary to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (S-Enantiomer)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.