Description

Onapristone is a potent, selective progesterone receptor antagonist with significant research and therapeutic potential. This compound is of critical importance in the study of hormone-dependent pathways and the development of targeted endocrine therapies. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract development organizations engaged in oncology, reproductive health, and endocrinology research.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the preclinical and clinical development of novel anti-progestins.
• Oncology Studies: Investigated for its potential in treating hormone-responsive cancers, such as breast, endometrial, and ovarian cancers, where progesterone receptors play a role.
• Reproductive Health Research: Used in studies focusing on fertility control, endometriosis, and uterine fibroids due to its antiprogestogenic activity.
• Endocrinology & Molecular Biology: A vital tool for elucidating the mechanism of action of progesterone receptors and their role in various physiological and pathological processes.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.

Basic Information

Product Name	Onapristone
CAS No.	96346-61-1
Molecular Formula	C₂₉H₃₅NO₄
Molecular Weight	461.60 g/mol
Synonyms	ZK 98299; ZK-98299; (8α,11β,13α,14β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(1-propynyl)gon-4-en-3-one; 11β-(4-Dimethylaminophenyl)-17β-hydroxy-17α-(1-propynyl)-estra-4,9-dien-3-one; ZK98299
EINECS	Contact for details

Quality Control

Our Onapristone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and NMR, to ensure it meets stringent research-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.